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Keep track of Intently (one)pentobarbital will minimize the level or effect of fentanyl intranasal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead to your reduce in fentanyl plasma concentrations, lack of efficacy or, possibly, enhancement of th